Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 8;7:59. doi: 10.3389/fendo.2016.00059

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Hosoi and Ozawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Possible mechanisms for the development of leptin resistance with obesity. Several mechanisms have been suggested for the development of leptin resistance: (1) impaired leptin transport across the blood–brain barrier (BBB), (2) the induction of suppressor of cytokine signaling 3 (SOCS3), (3) the induction/activation of protein tyrosine phosphatase 1B (PTP1B), and (4) endoplasmic reticulum (ER) stress have been suggested to play roles in the development of leptin resistance in obesity.