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. 2016 Jun 8;8:129. doi: 10.3389/fnagi.2016.00129

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Copyright © 2016 Chen, Wagener, Ghribi and Geiger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cholesterol-enriched diet impairs specific activities of endolysosome enzymes. Representative western blots were shown. The cholesterol-enriched diet (n = 9) increased significantly protein levels of acid phosphatase (A, ^∗p < 0.05), cathepsin D (C, ^∗p < 0.05), and cathepsin B (E, ^∗∗p < 0.01) in skeletal muscle, when compared with controls (n = 5). Cholesterol-enriched diet (n = 9) decreased significantly specific activities (ratio of total enzyme activity to protein levels as determined by immunoblotting) of acid phosphatase (B, ^∗p < 0.05), cathepsin D (D, ^∗p < 0.05), and cathepsin B (F, ^∗∗p < 0.01), when compared with controls (n = 5).