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. 2016 Jun 8;8:129. doi: 10.3389/fnagi.2016.00129

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Copyright © 2016 Chen, Wagener, Ghribi and Geiger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cholesterol-enriched diet increases the accumulation of AβPP in endolysosomes. (A) In muscle fibers from control rabbits, N-terminal AβPP positive signals were mainly present at plasma membrane and intramuscular signals were weak, but in muscles from cholesterol-fed rabbits AβPP positive signals appeared as large aggregates inside muscles (40X). (B) N-terminal AβPP positive staining (red) co-distributed with EEA1-positive staining of endosomes (green) and with LAMP2-positive staining of lysosomes (green) in muscle from cholesterol-fed rabbits. Bar = 20 μm. (C) Representative western blots were shown. Rabbits fed cholesterol-enriched diet (n = 9) exhibited significantly (^∗∗P < 0.01) increased protein levels of AβPP in skeletal muscle, when compared with controls (n = 5).