Table 2.

Minor allele frequencies (MAF) and age- and center-adjusted odds ratios for the associations between SNPs in insulin-like growth factor signaling genes and breast cancer risk.

Gene	SNP	Location	Major allele	Minor allele	European (641 cases, 806 controls)				East Asian (305 cases, 168 controls)
					MAF (controls)	Odds ratio	p-value	q-valuea	MAF (controls)	Odds ratio	p-value	q-valuea
IGF1	rs6214	3′UTR	G	A	0.43	0.90 (0.77, 1.04)	0.16	0.47	0.49	0.83 (0.63, 1.09)	0.17	0.44
IGF1	rs1549593	Intron	C	A	0.16	0.76 (0.61, 0.95)	0.01	0.11	0.02	0.72 (0.25, 2.13)	0.56	0.68
IGF1	rs17727841	Intron	C	G	0.19	1.00 (0.82, 1.21)	0.96	0.99	0.19	0.73 (0.51, 1.03)	0.07	0.39
IGF1	rs2288378	Intron	G	A	0.25	1.06 (0.89, 1.26)	0.52	0.82	0.19	0.71 (0.50, 1.01)	0.06	0.39
IGF1	rs7136446	Intron	A	G	0.42	1.09 (0.93, 1.26)	0.29	0.61	0.19	0.71 (0.50, 1.01)	0.06	0.39
IGF1	rs2195239	Intron	G	C	0.25	0.98 (0.83, 1.17)	0.84	0.98	0.46	0.94 (0.72, 1.23)	0.65	0.75
IGF1	rs7956547	Intron	A	G	0.27	0.97 (0.82, 1.15)	0.71	0.89	0.18	0.71 (0.50, 1.02)	0.07	0.39
IGF1	rs1019731b	Intron	C	A	0.15	0.67 (0.53, 0.84)	<0.01	0.01	0.00	N/A	N/A	N/A
IGF1	rs12821878c	Intron	G	A	0.24	0.73 (0.61, 0.88)	<0.01	0.01	0.04	1.25 (0.63, 2.49)	0.53	0.68
IGFBP3	rs6670	3′UTR	A	T	0.23	0.95 (0.80, 1.14)	0.57	0.84	0.01	2.41 (0.82, 7.06)	0.11	0.40
IGFBP3	rs2453839	Intron	A	G	0.19	1.04 (0.87, 1.25)	0.66	0.89	0.24	0.83 (0.60, 1.14)	0.24	0.49
IGFBP3	rs3110697	Intron	G	A	0.43	0.93 (0.80, 1.08)	0.36	0.66	0.29	0.86 (0.64, 1.15)	0.30	0.55
IGFBP3	rs2471551	Intron	G	C	0.22	0.90 (0.75, 1.08)	0.26	0.61	0.02	1.77 (0.74, 4.24)	0.20	0.44
IGFBP3	rs2132572	Promoter region	G	A	0.21	1.00 (0.84, 1.20)	0.99	0.99	0.25	0.81 (0.59, 1.11)	0.18	0.44
IGF1R	rs951715	Intron	A	G	0.34	1.14 (0.98, 1.33)	0.08	0.36	0.50	0.89 (0.68, 1.16)	0.38	0.59
IGF1R	rs2229765	Exond	G	A	0.44	1.03 (0.89, 1.19)	0.73	0.89	0.33	0.99 (0.74, 1.32)	0.95	0.99
IGF1R	rs8038415	Intron	A	G	0.49	1.00 (0.86, 1.15)	0.95	0.99	0.46	1.22 (0.93, 1.60)	0.15	0.44
IRS1	rs1801278	Exone	G	A	0.06	1.17 (0.87, 1.57)	0.31	0.61	0.02	0.39 (0.13, 1.16)	0.09	0.39
PI3KCB	rs12493155	Intron	G	A	0.45	1.07 (0.92, 1.23)	0.40	0.67	0.48	0.88 (0.68, 1.15)	0.35	0.59
PI3KCB	rs524164	Intron	G	A	0.47	0.90 (0.78, 1.04)	0.16	0.47	0.02	0.70 (0.26, 1.92)	0.49	0.68
PI3KCB	rs10513055	Intron	A	C	0.23	0.85 (0.71, 1.01)	0.07	0.36	<0.01	0.58 (0.04, 9.37)	0.70	0.77
PI3KCB	rs361072	Intron	A	G	0.47	0.90 (0.78, 1.05)	0.17	0.47	0.02	0.70 (0.26, 1.92)	0.49	0.68

SNPs with a q-value <0.05 are presented in bold.

^aFalse discovery rate-adjusted p-value.

^bGenotype frequencies of n_CC = 509, n_AC = 125, and n_AA = 7 among European cases; n_CC = 578, n_AC = 210, and n_AA = 18 among European controls.

^cGenotype frequencies of n_GG = 421, n_AG = 195, and n_AA = 25 among European cases; n_GG = 461, n_AG = 301, and n_AA = 44 among European controls.

^dSynonymous mutation.

^eGly/Arg substitution.