Table 4.
Heterogeneity in odds ratios between breast tumour subtypes for select IGF1 pathway SNPs among European and East Asian women.
| Ethnicity | Gene | SNP | Genotype | Tumor subtype |
pTHa | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ER+ and/or PgR+/HER2+ |
ER+ and/or PgR+/HER2− |
ER−/PgR−/HER2+ |
ER−/PgR−/HER2− |
|||||||||
| n | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) | |||||
| European | IGF1 | rs1549593 | CC | 56 | 0.82 (0.50, 1.36) | 307 | 0.74 (0.57, 0.96) | 25 | 0.64 (0.29, 1.44) | 84 | 0.76 (0.50, 1.17) | 0.96 |
| AC | 16 | 93 | 7 | 26 | ||||||||
| AA | 2 | 3 | 0 | 1 | ||||||||
| European | IGF1 | rs1019731 | CC | 62 | 0.49 (0.26, 0.89) | 320 | 0.65 (0.50, 0.85) | 25 | 0.67 (0.30, 1.50) | 87 | 0.76 (0.50, 1.17) | 0.68 |
| AC | 12 | 82 | 7 | 21 | ||||||||
| AA | 0 | 2 | 0 | 3 | ||||||||
| European | IGF1 | rs12821878 | GG | 52 | 0.61 (0.39, 0.96) | 270 | 0.70 (0.57, 0.87) | 20 | 0.71 (0.38, 1.35) | 70 | 0.81 (0.57, 1.15) | 0.79 |
| AG | 20 | 118 | 12 | 36 | ||||||||
| AA | 2 | 16 | 0 | 5 | ||||||||
| European | IGF1R | rs951715 | AA | 22 | 1.60 (1.14, 2.24) | 167 | 1.14 (0.96, 1.36) | 12 | 1.14 (0.69, 1.91) | 46 | 0.98 (0.73, 1.31) | 0.16 |
| AG | 36 | 172 | 16 | 55 | ||||||||
| GG | 16 | 65 | 4 | 10 | ||||||||
| European | PI3KCB | rs10513055 | AA | 49 | 0.74 (0.48, 1.15) | 260 | 0.81 (0.66, 1.00) | 16 | 1.11 (0.62, 1.99) | 64 | 1.00 (0.71, 1.39) | 0.45 |
| AC | 23 | 130 | 16 | 43 | ||||||||
| CC | 2 | 14 | 0 | 4 | ||||||||
| East Asian | IGF1 | rs2288378 | GG | 24 | 0.86 (0.44, 1.66) | 148 | 0.54 (0.35, 0.82) | 7 | 1.24 (0.49, 3.17) | 37 | 1.15 (0.68, 1.93) | 0.04 |
| AG | 12 | 37 | 6 | 11 | ||||||||
| AA | 0 | 2 | 0 | 6 | ||||||||
SNPs with a p-value for tumour heterogeneity are presented in bold.
ap-value for tumor heterogeneity in odds ratio by breast tumor subtype.