Table 2.
Effect of Isoproterenol in women using oral contraceptives.
| Control (n = 10) | Oral Contraceptive (n = 13) | Main effect of Isoproterenol | Main effect of Group | |
|---|---|---|---|---|
| DIAMETER (cm) | ||||
| Baseline | 0.33 ± 0.01 | 0.33 ± 0.01 | 0.565 | 0.885 |
| 1 ng/100 g/min | 0.34 ± 0.01 | 0.34 ± 0.01 | ||
| 3 ng/100 g/min | 0.34 ± 0.01 | 0.34 ± 0.01 | ||
| 6 ng/100 g/min | 0.34 ± 0.01 | 0.34 ± 0.01 | ||
| 12 ng/100 g/min | 0.34 ± 0.01 | 0.35 ± 0.01 | ||
| HEART RATE (beats/min) | ||||
| Baseline | 57 ± 3 | 66 ± 2 | 0.929 | <0.001 |
| 1 ng/100 g/min | 60 ± 2 | 65 ± 2 | ||
| 3 ng/100 g/min | 59 ± 3 | 65 ± 2 | ||
| 6 ng/100 g/min | 59 ± 3 | 66 ± 2 | ||
| 12 ng/100 g/min | 59 ± 3 | 68 ± 2 | ||
| MEAN ARTERIAL BLOOD PRESSURE (mmHg) | ||||
| Baseline | 83 ± 2 | 87 ± 2 | 0.0963 | 0.002 |
| 1 ng/100 g/min | 83 ± 2 | 86 ± 2 | ||
| 3 ng/100 g/min | 81 ± 2 | 86 ± 2 | ||
| 6 ng/100 g/min | 82 ± 2 | 87 ± 2 | ||
| 12 ng/100 g/min | 82 ± 3 | 87 ± 3 | ||
| FOREARM BLOOD FLOW (mL/min/100 g) | ||||
| Baseline | 4.9 ± 0.9 | 6.1 ± 0.6 | <0.001 | <0.001 |
| 1 ng/100 g/min | 7.1 ± 0.8 | 9.0 ± 0.8 | ||
| 3 ng/100 g/min | 9.3 ± 0.9A | 13.0 ± 1.1A | ||
| 6 ng/100 g/min | 13.4 ± 1.8ABC | 17.7 ± 1.8ABC | ||
| 12 ng/100 g/min | 16.0 ± 1.7ABC | 21.6 ± 1.9ABC | ||
| FOREARM VASCULAR CONDUCTANCE (mL/min/100 g/100 mmHg) | ||||
| Baseline | 5.8 ± 1.0 | 7.1 ± 0.7 | <0.001 | 0.002 |
| 1 ng/100 g/min | 8.4 ± 0.8 | 10.6 ± 1.1 | ||
| 3 ng/100 g/min | 11.4 ± 0.9A | 15.5 ± 1.6A | ||
| 6 ng/100 g/min | 16.4 ± 2.2ABC | 20.9 ± 2.6ABC | ||
| 12 ng/100 g/min | 19.3 ± 1.7ABC | 25.5 ± 2.7ABC | ||
Data are presented as Mean ± SEM.
A
p < 0.05 vs. Baseline;
B
p < 0.05 vs. 1 ng/100 g/min;
C
p < 0.05 vs. 3 ng/100 g/min. From the initial model which included Group-by-Isoproterenol interaction effect, no significant interaction was detected (p > 0.05). Bold values highlight significance.