. 2016 Jun 8;7:215. doi: 10.3389/fphys.2016.00215

Table 4.

Effect of Nitroprusside in women using oral contraceptives.

	Control (n = 10)	Oral Contraceptive (n = 13)	Main effect of Nitroprusside	Main effect of Group
Diameter (cm)
Baseline	0.34 ± 0.01	0.33 ± 0.01	<0.001	0.072
0.5 μg/100 g/min	0.35 ± 0.01^A	0.35 ± 0.01^A
1.0 μg/100 g/min	0.37 ± 0.01^A	0.36 ± 0.01^A
2.0 μg/100 g/min	0.39 ± 0.01^A ^B ^C	0.38 ± 0.01^A ^B ^C
Heart Rate (beats/min)
Baseline	59 ± 3	65 ± 3	0.329	<0.001
0.5 μg/100 g/min	57 ± 2	68 ± 4
1.0 μg/100 g/min	60 ± 2	71 ± 3
2.0 μg/100 g/min	62 ± 3	72 ± 3
Mean Arterial Blood Pressure (mmHg)
Baseline	86 ± 3	90 ± 2	0.009	0.039
0.5 μg/100 g/min	79 ± 3^A	85 ± 3^A
1.0 μg/100 g/min	79 ± 3^A	82 ± 2^A
2.0 μg/100 g/min	78 ± 2^A	80 ± 3^A
Forearm Blood Flow (mL/min/100 g)
Baseline	5.8 ± 0.9	6.9 ± 0.7	<0.001	0.004
0.5 μg/100 g/min	20.3 ± 3.5^A	24.0 ± 2.7^A
1.0 μg/100 g/min	22.8 ± 3.9^A	32.2 ± 3.5^A
2.0 μg/100 g/min	28.6 ± 5.0^A ^B ^C	40.7 ± 3.1^A ^B ^C
Forearm Vascular Conductance (mL/min/100 g/100 mmHg)
Baseline	6.7 ± 0.9	7.7 ± 0.8	<0.001	0.015
0.5 μg/100 g/min	25.6 ± 4.3^A	28.6 ± 3.8^A
1.0 μg/100 g/min	28.9 ± 4.9^A	39.7 ± 4.9^A
2.0 μg/100 g/min	36.7 ± 6.2^A ^B ^C	53.0 ± 5.7^A ^B ^C

Data are presented as Mean ± SEM.

p < 0.05 vs. Baseline;

p < 0.05 vs. 0.5 μg/100 g/min;

p < 0.05 vs. 1.0 μg/100 g/min. From the initial model which included Group-by-Nitroprusside interaction effect, no significant interaction was detected (p > 0.05). Bold values highlight significance.