Table 1.

Patient characteristics, Ig levels at diagnosis, B lymphocyte percentages, BTK expression and presence of mutation

Patient number	Age	Immunoglobulin levels at diagnosis (g/dl)			CD19+ B lymphocytesa		BTK expression	Mutation
		IgG	IgA	IgM	Diagnosis	Current
1	Pediatric	0.34	<0.05	0.084	<1 %	<1 %	Absent	N/A
2	Pediatric	<1.5	<0.02	<0.3	<1 %	<1 %	Diminished	Unknown
3	Pediatric	N/A	N/A	N/A	N/A	<1 %	Absent	Unknown
4	Pediatric	<0.33	<0.07	<0.11	<1 %	<1 %	Absent	Yes (c.877C>T)
5	Pediatric	<0.33	<0.7	<0.08	<2 %	<1 %	Absent	N/A
6	Pediatric	0.5	<0.07	0.33	<1 %	<1 %	Absent	Yes (c.1911delA)
7	Adult	N/A	N/A	N/A	<1 %	<1 %	Absent	Yes (R225X)
8	Adult	N/A	N/A	N/A	N/A	<1 %	Absent	Unknown
9	Adult	N/A	N/A	N/A	N/A	6 %	Absent	No
10	Adult	N/A	N/A	N/A	N/A	<1 %	Normal	N/A
11	Adult	N/A	N/A	N/A	N/A	<1 %	Absent	Unknown
12	Adult	N/A	N/A	N/A	<1 %	<1 %	Normal	N/A
13	Adult	N/A	N/A	N/A	7 %	<1 %	Absent	Unknown
14	Adult	N/A	N/A	N/A	N/A	<1 %	Absent	Yes (c.863G>A)
15	Adult	2.9	<0.48	0.15	N/A	<1 %	N/A	Unknown

N/A not available

^aAs percentage of total lymphocyte count