Table 1.

Key experimental details^∗.

Item	Experiment A [8]	Experiment B
Study design	Design: parallel crossover Diets: control (CON) and treatment (TRMT) Duration: 22 d with glucose kinetics assessed on day 19 of study	Design: parallel crossover Diets: control (CON) and treatment (TRMT) Duration: 63 d with glucose kinetics assessed on day 35 of study
Study population	A total of 6 neutered male Labrador Retrievers, 3-black-coated (3.9 yr; 27.3 kg) and 3-chocolate-coated (6.8 yr; 35.0 kg)	A total of 12 black Labrador Retrievers, 5 spayed females and 7 neutered males (27.0 ± 0.6 kg; 4.9 ± 0.2 yr of age)
Key details of glucose kinetics experiment	Isotope: U-13C-glucose Prime: 77.8 μmol/kg Constant: 0.136 μmol/min·kg Fasting collections (18 h since last meal): 6 blood samples were taken at 60, 85, 110, 135, 160, and 185 min followed by 4 breath samples taken at 220, 245, 270, and 295 min after isotope infusion (start of isotope infused considered time 0) Postprandial collections: total food ration of 14 g/kg divided into 15 equal sized meals fed in 25 min intervals; 6 blood samples were taken at 60, 85, 110, 135, 160, and 185 min followed by 4 breath samples taken at 220, 245, 270, 295, 320, and 345 min after initial meal	Isotope: U-13C-glucose Prime: 8.1 μmol/kg Constant: 0.136 μmol/min·kg Fasting collections (18 h since last meal): 6 fasting blood samples were taken at 90, 105, 120, 135, 150, and 165 min followed by 6 breath samples taken at 180, 205, 230, 255, 280, and 305 min after isotope infusion (start of isotope infused considered time 0) Postprandial collections: total food ration of 23 g/kg divided into 14 equal sized meals fed in 25 min intervals; 6 fasting blood samples were taken at 90, 105, 120, 135, 150, and 165 min followed by 6 breath samples taken at 180, 205, 230, 255, 280, and 305 min after initial meal.

^∗Isotope was delivered by primed constant intravenous infusion, blood samples were collected by jugular venipuncture, and breath was collected via indirect calorimetry.