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. 2016 Apr 22;26(6):728–742. doi: 10.1038/cr.2016.48

Figure 6.

Figure 6

Application of PNU282987 in the CA1 of the hippocampus suppressed seizure susceptibility in Chat-Mecp2−/y mice. (A) Representative EEG traces recorded from freely moving Chat-IRES-Cre and Chat-Mecp2−/y mice or PNU282987-treated Chat-Mecp2−/y mice. Bottom: Enlarged EEG traces showing baseline excitability discharges. (B) Incidence of spontaneous hyperexcitability in Chat-Mecp2−/y mice and their control littermates (Chat-IRES-Cre) or PNU282987-treated Chat-Mecp2−/y mice. χ2 test was used. (C) Percentage of pilocarpine-induced seizures in Chat-IRES-Cre and Chat-Mecp2−/y mice or PNU282987-treated Chat-Mecp2−/y mice. χ2 test was used. (D) Quantitative analysis of onset time for seizure induction in Chat-IRES-Cre and Chat-Mecp2−/y mice or PNU282987-treated Chat-Mecp2−/y mice. Two-way ANOVA was used. Error bars are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.