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. 2016 Apr 22;26(6):728–742. doi: 10.1038/cr.2016.48

Figure 7.

Figure 7

Delivery of nicotine or PNU282987 in the hippocampus rescued behavioral deficits manifested in Chat-Mecp2−/y mice. (A) Top: Microinjection of toluidine blue into the CA1 of the hippocampus. Shown is a representative section after injection. Bottom: Schematic of the protocol. (B-D) Anxiety-related behavior examined by the elevated plus-maze (EPM) and zero-maze. Data are time spent in the open arms of the EPM as well as number of entries and time spent in the lit compartment of the zero-maze. (E) Depression-related behavior was measured by the immobility time displayed in tail suspension. (F) Social behavior was measured as the ratio of interaction time with a stranger mouse to interaction time with a familiar mouse in the three-chamber test. P-values were calculated by two-way ANOVA (genotype × trial) with Bonferroni's post hoc comparison. Error bars are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.