(a).
| Batch code | Variable levels in coded formsb | Y 180 c | Y 1440 c | Y 2880 c | Percent drug loadd | |
|---|---|---|---|---|---|---|
| X 1 | X 2 | % | ||||
| F7 | −1 | −1 | 33.11 | 47.89 | 56.09 | 34.63 |
| F8 | −1 | 0 | 28.88 | 56.12 | 63.97 | 31.19 |
| F9 | −1 | 1 | 26.99 | 41.02 | 48.57 | 41.21 |
| F4 | 0 | −1 | 31.58 | 58.99 | 74.11 | 39.11 |
| F5 | 0 | 0 | 31.99 | 70.98 | 85.97 | 33.97 |
| F6 | 0 | 1 | 34.75 | 61.09 | 75.29 | 33.09 |
| F1 | 1 | −1 | 13.91 | 24.27 | 34.11 | 39.45 |
| F2 | 1 | 0 | 18.94 | 39.00 | 50.57 | 43.43 |
| F3 | 1 | 1 | 26.34 | 28.97 | 43.98 | 41.33 |
b X 1 indicated the amount of starch and X 2 the amount of PVA in mg.
c Y j denoted cumulative drug release at jth minutes.
dEvaluated on the basis of mass of Ornidazole used at the time of preparation and the mass of Ornidazole found entrapped in each formulation.