Table 2.
Cox-regression analysis of predictors of incidence of TB among HIV infected children at University of Gondar Referral Hospital (n = 271).
| Variables | TB incidence | CHR (95% CI) | AHR (95% CI) | |
|---|---|---|---|---|
| Event | Censored | |||
| Sex | ||||
| Male | 28 | 103 | 1 | |
| Female | 26 | 114 | 0.84 (0.49–1.43) | |
| Age | ||||
| <5 | 18 | 93 | 0.87 (0.41–1.84) | |
| 5–9 | 25 | 77 | 1.33 (0.65–2.69) | |
| 10–14 | 11 | 47 | 1 | |
| Residence | ||||
| Urban | 44 | 187 | 1 | |
| Rural | 10 | 30 | 1.58 (0.79–3.15) | |
| Family size | ||||
| ≤2 | 6 | 23 | 1 | |
| 3-4 | 31 | 119 | 0.94 (0.39–2.26) | |
| ≥5 | 17 | 75 | 0.82 (0.32–2.07) | |
| Parental status | ||||
| Both parents a live | 22 | 116 | 1 | |
| Paternal orphan | 17 | 39 | 2.05 (1.09–3.87) | |
| Maternal orphan | 7 | 27 | 1.26 (0.54–2.95) | |
| Double orphan | 5 | 29 | 0.90 (0.34–2.38) | |
| Not recorded | 3 | 6 | 2.27 (0.68–7.58) | |
| WHO clinical stage | ||||
| I | 10 | 73 | 1 | |
| II | 13 | 59 | 1.49 (0.65–3.41) | |
| III | 23 | 71 | 2.06 (0.98–4.33) | |
| IV | 8 | 14 | 3.66 (1.44–9.29) | |
| Anemia | ||||
| Anemia | 15 | 27 | 2.47 (1.36–4.49) | 2.23 (1.19–4.15) |
| No Anemia | 39 | 190 | 1 | |
| Immunodeficiency | ||||
| Severe | 20 | 77 | 1.08 (0.62–1.87) | |
| Not severe | 34 | 140 | 1 | |
| ART at initial | ||||
| Yes | 22 | 90 | 1.10 (0.64–1.91) | |
| No | 32 | 127 | 1 | |
| IPT | ||||
| Yes | 28 | 114 | 1.09 (0.64–1.85) | |
| No | 26 | 118 | 1 | |
| CPT | ||||
| Yes | 53 | 212 | 0.82 (0.11–5.96) | |
| No | 1 | 5 | 1 | |
| Past TB treatment history | ||||
| Yes | 11 | 34 | 0.82 (0.11–5.96) | |
| No | 43 | 183 | 1 | |
| Functional status | ||||
| Working | 13 | 88 | 1 | |
| Ambulatory | 37 | 111 | 2.21 (1.17–4.19) | 1.99 (1.04–3.81) |
| Bedridden | 4 | 18 | 1.50 (0.49–4.61) | 0.92 (0.29–2.92) |
| Vaccination status | ||||
| Vaccinated | 22 | 174 | 1 | |
| Not appropriately vaccinated | 31 | 22 | 7.86 (4.54–13.62) | 8.03 (4.61–13.97) |
| Not recorded | 1 | 21 | 0.36 (0.05–2.64) | 0.42 (0.06–3.15) |
| Nutritional status | ||||
| Normal | 19 | 84 | 1 | |
| Stunted | 35 | 133 | 1.07 (0.61–1.87) | |
COR = Crude hazard ratio, AOR = Adjusted Hazard Ratio, and CI = confidence interval.