Table 2.

3² full factorial design for the formulation of bucco-adhesive films of Buspirone Hydrochloride.

Formulation code	Amount of drug	Total amount of polymer	Amount of HPMC K15M		Amount of Eudragit RL-100		Amount of permeation enhancer		Amount of plasticizer		Solvents
		X 1	X 2				Na-lauryl sulphate		PEG 400		Water	Alcohol
	In mg		In %	In mg	In %	In mg	In %	In mL	In %	In mL	In mL	In mL
F1	50	150	100	150	0	0	5	0.009	20	0.03	15	0
F2	50	300	100	300	0	0	5	0.018	20	0.06	30	0
F3	50	450	100	450	0	0	5	0.027	20	0.09	45	0
F4	50	150	80	120	20	30	5	0.009	20	0.03	12	7.5
F5	50	300	80	240	20	60	5	0.018	20	0.06	24	15
F6	50	450	80	360	20	90	5	0.027	20	0.09	36	27.5
F7	50	150	66.66	100	33.33	50	5	0.009	20	0.03	10	12.5
F8	50	300	66.66	200	33.33	100	5	0.018	20	0.06	20	25
F9	50	450	66.66	300	33.33	150	5	0.027	20	0.09	30	37.5