Table 2.
Cox regression analysis by clinical, laboratory, substance use, and ART characteristics information of patients who started HHART in Zewditu Memorial Hospital, September 2008–February 2012 (n = 416).
| Variables | Alive | Dead | CHR (95% CI) | P value | AHR (95% CI) |
|---|---|---|---|---|---|
| WHO stage | |||||
| 1-2 | 183 | 7 | 1.0 | 1.0 | |
| 3-4 | 196 | 30 | 3.89 (1.71, 8.86)∗ | 0.001 | 2.99 (1.26, 5.31)∗ |
| Hemoglobin in gm/dL | |||||
| <10 | 31 | 9 | 6.55 (3.27, 13.12)∗ | 0.001 | 5.54 (2.58, 11.86)∗ |
| ≥10 | 285 | 24 | 1.0 | 1.0 | |
| CD4 count cells/µL | |||||
| <50 | 54 | 9 | 0.52 (0.24, 1.11) | 0.09 | 0.77 (0.33, 1.83) |
| ≥50 | 306 | 24 | 1.0 | 1.0 | |
| BMI in kg/m2 | |||||
| <18.5 | 26 | 2 | 1.13 (0.23, 5.43) | 0.882 | |
| ≥18.5 | 108 | 7 | 1.0 | ||
| Past TB treatment | |||||
| No | 337 | 28 | 1.0 | 1.0 | |
| Yes | 38 | 9 | 2.90 (1.36, 6.17)∗ | 0.006 | 4.13 (1.79, 9.51)∗ |
| Tobacco use | |||||
| Nonuser | 293 | 22 | 1.0 | — | |
| User | 81 | 15 | 0.85 (0.37, 1.93) | 0.691 | |
| Soft drug (kchat, shisha) use | |||||
| Nonuser | 252 | 26 | 1.0 | — | |
| User | 126 | 11 | 0.82 (0.41, 1.67) | 0.586 | |
| Hard drug (iv drug,…) use | |||||
| Nonuser | 342 | 36 | 1.0 | 0.235 | 1.0 |
| User | 33 | 1 | 0.30 (0.04, 2.19) | 0.73 (0.09, 5.65) |
A cox proportional hazards model adjusted for all variables listed in the table. HR: hazard ratio; CI: confidence interval; ART: antiretroviral therapy; WHO: World Health Organization; BMI: body mass index.
∗indicates that the variables significantly associated with the outcome at 95% level of significant (P < 0.001).