Fig. 5.
Current model of the tenogenic cascade and TNMD involvement. TNMD is marked in orange, transcription factors in blue and other genes in black. Based on Alberton et al. 2015; Berasi et al. 2011; Eloy-Trinquet et al. 2009; Havis et al. 2014; Huang et al. 2015; Lee et al. 2015; Liu et al. 2014; Mienaltowski et al. 2013; Pryce et al. 2009; Shen et al. 2013; Tempfer et al. 2009. Abbreviations: Aqp1, aquaporin 1; BMP, bone morphogenetic protein; Col, collagen; COMP, cartilage oligomeric matrix protein; Egr, early growth response protein; Eya, eyes absent transcription factor; FGF, fibroblast growth factor; Htra3, HtrA serine peptidase 3; IFM, interfascicular matrix; Mkx, Mohawk; Sca-1, stem cells antigen-1; Scx, scleraxis; SMA, smooth muscle actin; TGF, transforming growth factor; Thbs, thrombospondin; Tnmd, tenomodulin.