Table 2. Antagonistic effects of rikkunshito components against 5-HT_2CR.

Components	Crude drug	IC50 (μmol/L)
Hesperetin	Citri Unshiu Pericarpium	48.2*
Isoliquiritigenin	Glycyrrhizae Radix	5.5*
Glycycoumarin	Glycyrrhizae Radix	7.7*
[8]-Shogaol	Zingiberis Rhizoma	36.9*

^*IC₅₀ (μmol/L) values for the cell function assay have been previously reported by Nahata et al.¹³.