Table 2.

Association between CRP and SAA levels and measurable risk factors in Taiwanese.

Clinical and biochemical parameters		CRP level				SAA level
		r	β (95% CI)	P value∗	Adjusted P value	r	β (95% CI)	P value∗	Adjusted P value
Anthropology	Body mass index	0.318	0.045 (0.034–0.056)	1.9 × 10−15	6.1 × 10−14	0.121	0.017 (0.006–0.028)	0.003	0.096
	Waist-hip ratio	0.221	1.793 (1.157–2.430)	4.7 × 10−8	1.5 × 10−6	0.061	0.488 (−0.156–1.131)	0.137	NS
Blood pressure	Systolic BP	0.178	0.006 (0.003–0.008)	3.6 × 10−5	0.001	0.132	0.004 (0.001–0.007)	0.003	0.096
	Diastolic BP	0.152	0.008 (0.003–0.012)	4.4 ×10−4	0.014	0.141	0.007 (0.003–0.011)	0.001	0.032
Glucose metabolism	Fasting plasma glucose	0.139	1.056 (0.493–1.618)	0.001	0.032	0.002	0.001 (−0.568–0.570)	0.996	NS
	HOMA-IR index	0.299	0.778 (0.605–0.951)	1.2 × 10−17	3.9 × 10−16	0.138	0.335 (0.151–0.519)	0.001	0.032
Lipid profiles	LDL cholesterol	0.055	0.001 (0.000–0.002)	0.185	NS	0.032	<0.001 (−0.001–0.002)	0.449	NS
	HDL cholesterol	−0.246	−1.161 (−1.532 to −0.790)	1.4 × 10−9	4.6 × 10−8	0.074	0.345 (−0.036–0.725)	0.076	NS
	Triglyceride	0.267	0.528 (0.373–0.683)	5.0 × 10−11	1.6 × 10−9	0.095	0.186 (0.026–0.345)	0.022	0.704
Renal function	Urinary ACR	0.011	<0.001	0.783	NS	0.028	<0.001	0.501	NS
	Uric acid	0.227	0.077 (0.048–0.106)	3.8 × 10−7	1.2 × 10−5	0.131	0.043 (0.014–0.071)	0.004	0.128
	eGFR	0.196	0.006 (0.003–0.008)	1.1 × 10−5	3.5 × 10−4	0.030	0.001 (−0.002–0.003)	0.502	NS
Inflammatory markers	CRP	—	—	—	—	0.414	0.406 (0.334–0.479)	9.1 × 10−26	2.9 × 10−24
	SAA	0.414	0.423 (0.347–0.498)	9.1 × 10−26	2.9 × 10−24	—	—	—	—
	Fibrinogen	0.308	0.002 (0.002–0.003)	1.4 × 10−14	4.5 × 10−13	0.178	0.001 (0.001–0.002)	1.4 × 10−5	4.5 × 10−4
	sE-selectin	0.272	0.681 (0.486–0.877)	1.8 × 10−11	5.8 × 10−10	0.101	0.251 (0.051–0.451)	0.014	0.448
	sP-selectin	0.044	0.071 (−0.059–0.200)	0.287	NS	−0.004	−0.007 (−0.136–0.122)	0.916	NS
	sVCAM1	0.032	0.154 (−0.235–0.544)	0.436	NS	0.028	0.131 (−0.252–0.515)	0.502	NS
	sICAM1	0.126	0.331 (0.120–0.541)	0.002	0.064	0.019	0.049 (−0.160–0.258)	0.645	NS
	sTNFRII	0.180	0.753 (0.421–1.084)	1.0 × 10−5	3.2 × 10−4	0.073	0.299 (−0.034–0.631)	0.078	NS
	IL6	0.316	0.468 (0.372–0.564)	9.5 × 10−15	3.1 × 10−14	0.165	0.197 (0.102–0.291)	4.9 × 10−5	0.002
	MCP1	0.031	0.05 (−0.080–0.180)	0.452	NS	0.012	0.019 (−0.112–0.150)	0.772	NS
	MMP1	0.045	0.045 (−0.036–0.126)	0.275	NS	−0.002	−0.002 (−0.082–0.078)	0.959	NS
	MMP2	−0.119	−0.469 (−0.784 to −0.154)	0.004	0.128	−0.043	−0.235 (−0.548–0.078)	0.297	NS
	MMP9	0.077	0.146 (−0.007–0.299)	0.062	NS	0.076	0.145 (−0.008–0.297)	0.064	NS
Adipokines	Leptin	0.225	0.442 (0.325–0.559)	2.8 × 10−8	9.0 × 10−7	0.131	0.289 (0.169–0.409)	0.001	0.032
	Resistin	0.082	0.150 (0.000–0.301)	0.050	NS	−0.019	−0.034 (−0.183–0.116)	0.659	NS
	Lipocalin-2	0.136	0.310 (0.124–0.495)	0.001	0.032	0.085	0.190 (0.005–0.376)	0.044	NS
	Adiponectin	−0.251	−0.447 (−0.586 to −0.308)	5.3 × 10−10	1.7 × 10−8	−0.007	−0.013 (−0.155–0.129)	0.862	NS

  ^∗ P value was adjusted for age and sex.

Adjust P values were computed by Bonferroni method, NS (not significant) if adjusted P value above 1.0.

Abbreviations are as in Table 1; BP levels, lipid variables, and uric acid levels were analyzed with the exclusion of subjects using antihypertensive drugs, lipid-lowering agents, and uric acid lowering agents, respectively. Fasting plasma glucose and insulin, QUICKI, and HOMA-IR index were analyzed with the exclusion of antidiabetic medications. Albumin-to-creatinine ratio (ACR) (mg/g) was analyzed with the exclusion of subjects with macroalbuminuria.