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. 2016 Jun 8;6:27486. doi: 10.1038/srep27486

Figure 1. Chronic inflammation and ER stress in adipose tissue of high-fat diet induced-obesity.

Figure 1

Mice were fed a regular diet (RD) or high-fat diet (HFD) for 14 weeks. (a) Body weights of HFD mice and RD mice. Mice fed a high-fat diet (n = 10) had higher weights compared with mice fed a regular diet (n = 10). (b) H&E staining of adipose tissue. Adipocytes hypertrophy and macrophage infiltration were observed in mice fed a high-fat diet for 14 weeks. (c) Protein expression levels of ER stress markers in adipose tissue. Protein expression levels of each ER stress marker were significantly up-regulated in mice fed a high-fat diet for 14 weeks. (d) Gene expression levels and blood protein levels of inflammatory cytokines in adipose tissue. mRNA expression levels of inflammatory cytokines were significantly up-regulated in mice fed a high-fat diet for 14 weeks. (e) The adipocytes TC and FC were elevated in high-fat diet mice. Data are presented as the means ± SD. *p < 0.05, **p < 0.01 (Compared with RD group).