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. 2016 Jun 8;6:27486. doi: 10.1038/srep27486

Figure 4. IKK/NF-κB pathway in the signal transduction of adipokine expression regulating by ER stress.

Figure 4

3T3-L1 preadipocytes were cultured and induced to differentiate into mature adipocytes. ER stress was triggered by TM, then PS1145 was added to inhibit NF-κB pathway. (a) Nucleus expression levels of NF-κB in adipocytes were down-regulated by treatment with PS1145. (b) Gene expression levels of inflammatory cytokines in adipose tissue. The mRNA expression levels of resistin and TNF-α were down-regulated by treatment with PS1145. Values are means ± SD. *p < 0.05, **p < 0.01 (compared with control group).