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. 2016 Jun 8;6:27665. doi: 10.1038/srep27665

Figure 4. CD74 and CD44 mediated MCP-1 increase in hepatocytes.

Figure 4

AML-12 cells were transfected with SCR siRNAs, CD74 siRNAs or CD44 siRNAs. After 48 hours, cells were treated with rMIF or LPS for another 6 hours or CCl4 for another 3 hours. The mRNA expressions of CD74 (a) and CD44 (e) were examined to confirm the knockdown efficiency. MCP-1 mRNA expression were evaluated by real-time RT-PCR (b–d,f–h). All results were confirmed in three independent experiments at least. *P < 0.05 vs untreated control cells. #P < 0.05 vs rMIF, LPS or CCl4 treated cells alone.