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. 2016 Jun 6;7:11790. doi: 10.1038/ncomms11790

Figure 6. Splice patterns over fusion breakpoints.

Figure 6

Illustration of all detected fusion breakpoints in BCP ALL cases with (a) BCR-ABL1, (b) ETV6-RUNX1, (c) MLL fusions, and (d) TCF3-PBX1. Genes are arranged clockwise by genomic position. The outer circle represents the genomic region encompassing the indicated genes. Yellow indicates untranslated regions, green indicates coding exons, and red and grey indicate intronic regions (the latter are not to scale). The inner circle represents one or two overlaid reference transcripts of the indicated gene. Coding exons are indicated by a thick line with white arrows indicating the direction of the gene, introns are indicated by a thin or dashed line and untranslated regions are indicated by a medium thick line. Connecting lines between transcripts illustrate fusion breakpoints detected by at least three (for BCR-ABL1, ETV6-RUNX1 and MLL fusions) or ten reads (for TCF3-PBX1). Fusion breakpoints in individual BCP ALL cases are depicted in Supplementary Figs 15–18.