Table 2.

Association between genetic polymorphisms and Hg levels in hair, blood and urine. Significantly different values (p<0.05) are shown in bold. Only genes with significant ANOVA tests are shown here and all other SNPs can be found in Supplementary Table 1.^*

Category	Gene symbol	SNPs	n	MAF	Hair Hg (μg/g)			Blood Hg (μg/L) Geometric Mean + Arithmetic SD			Urine Hg (μg/L)
					1 Major	2 Heterozy	3 Minor	1 Major	2 Heterozy	3 Minor	1 Major	2 Heterozy	3 Minor
Glutathione	GCLC	rs17883901	380	0.08	0.60±0.977	0.73±1.197	2.92±0.417	3.60±4.018	4.60±3.548	9.65±2.308	1.31±1.72	1.34±2.06	2.21±0.86
	GLRX2	rs912071	376	0.37	0.52±0.8810	0.72±1.0910	0.65±1.1010	3.47±4.05	4.04±4.01	3.57±3.73	1.37±1.75	1.34±1.69	1.09±1.80
	GSTA4	rs367836	380	0.34	0.64±1.01	0.59±0.97	0.67±1.22	4.05±4.0711	3.35±3.6611	4.50±4.5511	1.46±1.80	1.21±1.74	1.31±1.68
	GSTP1	rs1695	380	0.33	0.65±1.22	0.61±0.79	0.57±0.75	4.22±4.436	3.45±3.426	3.15±3.496	1.23±1.93	1.38±1.65	1.48±1.48
	GSTP1	rs1138272	380	0.06	0.65±1.04	0.46±0.69		3.87±3.969	2.91±3.999		1.29±1.77	1.59±1.72
Glutathione and Selenoprotein	GPX6	rs6413428	380	0.18	0.62±1.07	0.60±0.72	0.81±1.46	3.75±4.26	3.54±3.16	5.17±3.42	1.20±1.4928	1.69±2.1728	1.29±2.0328
Selenoprotein	SEPN1	rs7349185	369	0.15	0.65±1.06	0.55±0.93	0.71±0.64	4.00±3.84	3.18±4.46	4.66±3.15	1.31±1.9026	1.24±1.2526	2.36±1.3126
	SEPN1	rs2294228	380	0.17	0.64±0.95	0.56±1.18	0.90±0.82	3.93±3.58	3.22±4.56	4.98±5.90	1.27±1.8827	1.36±1.4427	2.41±1.3427
	SEPHS2	rs1133238	379	0.08	0.64±1.03	0.51±0.85		3.84±4.00	3.25±3.58		1.38±1.7625	1.03±1.7325
	SEPP1	rs3877899	379	0.18	0.62±1.07	0.61±0.73	0.81±1.46	3.75±4.25	3.58±3.17	5.17±3.42	1.20±1.4924	1.70±2.1924	1.29±2.0324
Selenoprotein/Oxidative Stress	TXNRD2	rs5748469	380	0.49	0.66±0.9121	0.54±0.9921	0.74±1.1421	3.52±3.6122	3.41±3.9422	4.70±4.2522	1.53±1.93	1.25±1.60	1.22±1.79
	TXNRD3	rs3108755	322	0.05	0.61±1.09	0.61±0.56		3.73±4.12	3.98±3.36		1.37±1.7323	0.93±1.3123
Metallothionein	MT1B	rs7191779	380	0.48	0.77±1.0719	0.60±0.9519	0.53±1.0519	3.90±3.90	3.67±3.87	3.73±4.24	1.30±1.96	1.36±1.77	1.27±1.50
	MT1B	rs8052334	379	0.48	0.76±1.0620	0.59±0.9420	0.54±1.0620	3.89±3.89	3.65±3.83	3.73±4.26	1.29±1.95	1.36±1.76	1.25±1.50
	MT1M	rs2270836	378	0.35	0.81±1.1015	0.50±0.9815	0.52±0.6415	4.39±4.0016	3.42±3.7416	2.94±4.2916	1.25±1.41	1.34±2.05	1.43±1.70
	MT4	rs11643815	352	0.09	0.68±0.9717	0.41±0.5517	0.27±0.4217	3.93±3.8018	3.17±2.7518	1.76±1.7918	1.37±1.77	1.33±1.93	1.19±1.32
Transporter	ABCB1	rs9282564	380	0.06	0.63±1.05	0.54±0.71		3.88±4.0834	2.89±2.6334		1.28±1.73	1.63±1.93
	ATP7B	rs1801243	377	0.48	0.72±0.88	0.59±0.94	0.61±1.27	3.80±3.75	3.74±3.80	3.76±4.53	1.31±1.7613	1.48±1.7713	1.10±1.7413
	SLC7A7	rs2281677	379	0.37	0.72±0.9930	0.59±1.1130	0.47±0.6230	3.87±3.93	3.66±4.02	3.61±3.86	1.43±1.77	1.30±1.89	1.14±1.08
	SLC22A6	rs4149170	362	0.11	0.60±1.00	0.70±0.77	0.83±0.57	3.61±3.85	4.31±3.99	5.52±1.85	1.39±1.8033	1.03±1.4033	1.75±3.2533
	SLC22A8	rs4149182	380	0.23	0.58±1.10	0.70±0.90	0.69±0.55	3.35±3.9029	4.51±4.1929	4.01±2.2329	1.29±1.84	1.34±1.70	1.57±1.39
	SLC43A2	rs4790732	380	0.34	0.56±0.8131	0.64±1.1331	0.85±1.1531	3.29±3.7132	3.98±4.2632	4.81±3.6132	1.30±1.77	1.37±1.62	1.24±2.17
Methylation/Folate Pathway	DNMT1	rs2228613	380	0.06	0.65±1.044	0.43±0.704		3.89±4.0135	2.77±3.4035		1.33±1.80	1.26±1.36
	MTHFR	rs2274976	380	0.09	0.63±1.02	0.60±0.99	0.57±0.27	3.79±4.01	3.52±3.68	4.58±5.53	1.39±1.805	1.04±1.525	0.78±0.975
Hemoglobin	HBS1L	rs4895441	378	0.26	0.58±0.90	0.69±1.14	0.57±1.07	3.68±3.74	3.94±4.28	3.12±3.77	1.43±1.8912	1.24±1.6612	0.95±0.9112

¹Major: major homozygotes,

²Heterozy: heterozygote,

³Minor: minor homozygote, MAF: Minor allele frequency, Hg: mercury, SD: Standard deviation, n: number of participants, SNP: single nucleotide polymorphism

^*Details of superscript values 3–35 are provided in the Supplementary Table 1.

For SNPs with <3 individuals in the minor homozygote category, heterozygotes and minor homozygotes were combined before calculating GMs shown here.