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. 2016 Jun 8;6:27607. doi: 10.1038/srep27607

Figure 4. Effect of adrenalectomy and/or adrenergic receptor blockers on the treadmill exercise-induced phase advance of peripheral clocks.

Figure 4

(a) Experimental schedule. The white and black bars indicate environmental 12 h light and dark conditions. The orange short bar indicates exercise periods. The black arrow indicates the periods of measurement using IVIS. The green arrow indicates the injection time of the blocker. ADX, adrenalectomized mice. Blockers, prazosin hydrochloride (1 mg/kg i.p.) and propranolol hydrochloride (2 mg/kg) were administered 30 min before exercise for 3 consecutive days. (b) The average peak phase of PER2::LUC rhythms in each tissue under different experimental conditions. All values are represented as mean ± SEM (No-Ex intact, n = 8; T-Ex intact, n = 6; T-Ex ADX, n = 6; T-Ex Blocker, n = 6; T-Ex ADX + Blocker, n = 5). $$p < 0.01 $p < 0.05 versus T-Ex intact, evaluated using the Kruskal-Wallis test with Dunn post-hoc test. No exercise or treadmill exercise: No-Ex or T-Ex, respectively.