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. 2016 Jun 8;7:825. doi: 10.3389/fmicb.2016.00825

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Copyright © 2016 Gutiérrez, Rodríguez-Rubio, Martínez, Rodríguez and García.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Location of exopolysaccharide depolymerase degrading β-(1,6) bonds of the biofilm extracellular matrix (PIA/PNAG) of staphylococcal species in the phage particle and mode of action. (B) Location of virion-associated peptidoglycan hydrolase (VAPGH) at the phage particle and its role in the infection process. (C) Structure of Gram-positive bacteria cell wall and role of the endolysin during the bacterial lysis. (D) Activity of phage derived proteins when added exogenously and their application as anti-biofilm agents degrading polysaccharidic matrices (polysaccharide depolymerases) and lysing bacteria (VAPGHs and endolysins).