Table 3.
Subgroup analyses
| Subgroup | Studies | Sensitivity (95 %) | Specificity (95 %) | PLR (95 %) | NLR (95 %) | SDOR (95 %) | AUC | Q* |
|---|---|---|---|---|---|---|---|---|
| All | 21 | 0.77 (0.74, 0.79) | 0.74 (0.72, 0.75) | 3.58 (2.85, 4.49) | 0.29 (0.22, 0.37) | 15.18 (9.75, 23.62) | 0.8666 | 0.7972 |
| Infection | ||||||||
| Proven | 7 | 0.82 (0.75, 0.87) | 0.74 (0.71, 0.77) | 4.14 (2.56, 6.68) | 0.17 (0.06, 0.52) | 30.58 (9.75, 95.88) | 0.9136 | 0.8461 |
| Clinical | 5 | 0.74 (0.70, 0.77) | 0.66 (0.62, 0.69) | 2.19 (1.72, 2.79) | 0.39 (0.25, 0.62) | 6.98 (3.68, 13.24) | 0.8245 | 0.7576 |
| Clinical or Proven | 9 | 0.78 (0.75, 0.81) | 0.79 (0.77, 0.82) | 3.93 (2.81, 5.49) | 0.27 (0.21, 0.36) | 15.41 (8.76, 27.09) | 0.8661 | 0.7967 |
| Type of sepsis | ||||||||
| Early-onset | 7 | 0.75 (0.72, 0.78) | 0.74 (0.72, 0.76) | 3.57 (2.49, 5.11) | 0.31 (0.23, 0.42) | 12.40 (6.40, 24.00) | 0.8415 | 0.7732 |
| Late-onset | 6 | 0.79 (0.75, 0.82) | 0.71 (0.68, 0.74) | 3.42 (2.11, 5.55) | 0.24 (0.14, 0.41) | 18.86 (6.82, 52.16) | 0.9262 | 0.8606 |
| Early & late-onset | 8 | 0.78 (0.72, 0.84) | 0.79 (0.74, 0.84) | 3.65 (2.93, 4.57) | 0.26 (0.11, 0.59) | 20.43 (12.31, 33.91) | 0.8835 | 0.8140 |
| Infants | ||||||||
| Preterm | 8 | 0.74 (0.71, 0.77) | 0.69 (0.67, 0.71) | 2.76 (2.16, 3.54) | 0.37 (0.30, 0.47) | 7.83 (4.84, 12.68) | 0.8088 | 0.7436 |
| Term | 2 | 0.80 (0.74, 0.85) | 0.85 (0.82, 0.88) | 5.75 (3.08, 10.72) | 0.24 (0.18, 0.31) | 24.07 (13.17, 44.01) | -- | -- |
| Preterm + term | 11 | 0.81 (0.76, 0.84) | 0.81 (0.78, 0.84) | 3.88 (3.04, 4.97) | 0.21 (0.11, 0.41) | 22.84 (12.94, 40.29) | 0.8853 | 0.8159 |