Table 2.
Clinical variables (median, 25 and 75 percentile, mean ± SD at baseline, after 3 and 6 months, differences and statistical analysis
| N test group = 23 N control group = 23 |
Baseline | 3 months | 6 months | Difference t0-t3 | Difference t0-t6 |
|---|---|---|---|---|---|
| BoP (%) | |||||
| Test Control |
17.0 (13.0, 19.0) *** 16.0 (13.0, 19.0) *** |
6.0 (4.0, 9.0) *** †† 9.0 (5.0, 12.0) *** |
12.0 (9.0, 14.0) *** 11.0 (8.0, 17.0) *** |
10.0 (8.0, 12.0) *** † 9.0 (6.0, 11.0) *** |
5.0 (3.0, 8.0) *** 4.0 (2.0, 7.0) *** |
| Test Control |
16.5 ± 4.0 16.7 ± 5.5 |
6.2 ± 3.0 8.7 ± 3.7 |
11.5 ± 4.9 13.0 ± 6.7 |
10.3 ± 3.1 8.0 ± 4.0 |
5.0 ± 4.0 3.7 ± 5.6 |
| SBI (%) | |||||
| Test group Control group |
18.0 (14.0, 23.0) *** 16.0 (14.0, 21.0) *** |
12.0 (8.0, 15.0) *** 11.0 (7.0, 15.0) *** |
13.0 (11.0, 18.0) *** 13.0 (11.0, 15.0) *** |
7.0 (4.0, 11.0) *** 8.0 (4.0, 12.0) *** |
4.0 (0.0, 8.0) ** 4.0 (3.0, 8.0) ** |
| Test Control |
18.7 ± 6.5 18.1 ± 5.6 |
11.8 ± 4.4 10.3 ± 4.3 |
13.4 ± 5.2 13.4 ± 3.8 |
6.8 ± 5.2 7.8 ± 5.4 |
5.2 ± 5.7 4.7 ± 5.9 |
| Mean PD (mm) | |||||
| Test Control |
3.3 (3.1, 3.6) *** 3.2 (3.1, 3.5) *** |
2.1 (2.0, 2.2) *** †† 2.2 (2.0, 2.5) *** |
2.2 (2.0, 2.3) *** †† 2.3 (2.1, 2.5) *** |
1.2 (0.8, 1.2) *** † 1.0 (0.9, 1.5) *** |
1.1 (0.8, 1.2) *** 1.0 (0.8, 1.5) *** |
| Test Control |
3.3 ± 0.4 3.3 ± 0.3 |
2.1 ± 0.3 2.3 ± 0.2 |
2.2 ± 0.2 2.3 ± 0.3 |
1.2 ± 0.3 1.0 ± 0.3 |
1.1 ± 0.3 1.0 ± 0.3 |
| Mean AL (mm) | |||||
| Test group Control group |
3.5 (3.3, 3.7) *** 3.5 (3.3, 3.7) *** |
2.5 (2.4, 2.6) *** †† 2.8 (2.5, 2.9) *** |
2.6 (2.5, 2.7) *** †† 2.8 (2.7, 3.0) *** |
0.9 (0.8, 1.1) *** ††† 0.7 (0.6, 0.8) *** |
0.9 (0.7, 1.0) *** ††† 0.6 (0.5, 0.7) *** |
| Test Control |
3.5 ± 0.2 3.4 ± 0.3 |
2.5 ± 0.3 2.7 ± 0.3 |
2.6 ± 0.2 2.8 ± 0.3 |
1.0 ± 0.3 0.7 ± 0.2 |
0.9 ± 0.2 0.6 ± 0.2 |
| Sites PD > 5 mm (n) | |||||
| Test Control |
18.0 (13.0,27.0) 19.0 (9.0, 25.0) |
0.0 (0.0, 2.0) 1.0 (0.0, 5.0) |
0.0 (0.0, 2.0) 2.0 (0.0, 6.0) |
17.0 (13.0, 26.0) 17.0 (8.0, 22.0) |
18.0 (13.0, 25.0) 16.0 (7.0, 22.0) |
| Test Control |
18.7 ± 10.3 19.4 ± 13.0 |
1.1 ± 1.7 2.7 ± 3.3 |
1.3 ± 2.2 3.4 ± 4.2 |
17.6 ± 9.2 16.7 ± 10.2 |
17.4 ± 8.7 16.0 ± 9.9 |
| Mean sites PD > 5 mm (n) | |||||
| Test Control |
5.3 (5.0, 5.5) 5.3 (5.0, 5.5) |
3.0 (2.8, 3.3) 3,0 (2.8, 3.3) |
3.0 (2.8, 3.5) 3.0 (2.8, 3.3) |
2.5 (2.3, 2.5) 2.3 (2.0, 2.5) |
2.3 (2.0, 2.5) 2.3 (2.0, 2.3) |
| Test Control |
5.3 ± 0.4 5.3 ± 0.4 |
3.0 ± 0.4 3.0 ± 0.3 |
3.1 ± 0.4 3.1 ± 0.3 |
2.3 ± 0.2 2.3 ± 0.3 |
2.2 ± 0.3 2.2 ± 0.4 |
| Sites AL > 5 mm (n) | |||||
| Test Control |
21.0 (14.0, 31.0) 21.0 (12.0, 27.0) |
2.0 (0.0, 3.0) 2.0 (0.0, 6.0) |
1.0 (0.0, 3.0) 3.0 (0.0, 8.0) |
21.0 (14.0, 27.0) 16.0 (12.0, 24.0) |
21.0 (14.0, 27.0) 16.0 (9.0, 23.0) |
| Test Control | 21.3 ± 11.5 22.3 ± 14.7 |
2.1 ± 3.3 3.4 ± 4.2 |
2.4 ± 3.7 4.3 ± 4.4 |
19.2 ± 9.5 18.9 ± 11.7 |
18.9 ± 9.1 18.0 ± 11.7 |
| Mean sites AL > 5 mm (n) | |||||
| Test Control |
4.0 (4.0, 4.3) 4.0 (4.0, 4.3) |
2.8 (2.8, 3.0) 3.0 (2.8, 3.0) |
3.0 (3.0, 3.0) 3.0 (3.0, 3.3) |
1.3 (1.3, 1.5) 1.3 (1.0, 1.5) |
1.0 (1.0, 1.3) 1.0 (0.8, 1.3) |
| Test Control |
4.2 ± 0.3 4.1 ± 0.2 |
2.9 ± 0.2 2.9 ± 0.3 |
3.1 ± 0.2 3.1 ± 0.2 |
1.3 ± 0.2 1.2 ± 0.3 |
1.1 ± 0.3 1.0 ± 0.2 |
Wilcoxon signed rank test: significant longitudinal changes t3 - t0, t6 - t0 within each group
** 0.01 < p < 0.05, *** p < 0.001
Mann Whitney test between the groups (test-control): † 0.05 < p < 0.1, †† 0.01 < p < 0.05, ††† < 0.001