Table.

Effects of ETS-1 and Renin–Angiotensin System Blockade on Proteinuria, TGF-β, Angiotensinogen Urinary Excretion, and Cortical Angiotensin II

	NS	HS	HS/DN	HS/MU	HS/ARB	HS/DN/ARB
Proteinuria, mg/24 h	44.8±3.9	91.3±6.1*	65.3±6.6*†	82.8±16.3*	51.9±3.2†	42.5±3.0†‡
Albuminuria, mg/24 h	3.7±1.1	56.4±17.2*	25.4±2.7*†	36.0±10.5*	11.8±6.4†	11.6±1.8†
Urinary TGF-β, pg/24 h	13.0±8.8	417±87.6*	142.2±64.9*†	498.3±138.3*	604.1±94.9*	23.0±9.3†‡
Angiotensinogen, ng/24 h	382.8±153	1105±148*	538.4±114†	812.2±372.9*	446±81.2†	330.2±116†
Renal cortical angiotensin II, fmol/g	1237±212	3197±675*	1008.6±127	1525.6±298†	927.2±204†	1352±397†

Data are presented as mean±SEM. ARB indicates angiotensin II receptor I blocker; DN, dominant negative peptide; ETS-1, transcription factor avian virus E26 oncogen homolog-1; HS, high-salt diet; MU, mutant peptide; NS, normal-salt diet; and TGF-β, transforming growth factor-β.

^*P<0.05 vs NS.

^†P<0.05 vs HS.

^‡P<0.05 vs HS/DN and HS/ARB.