Figure 4.
Nelfinavir suppresses cervical tumor growth in vivo.
Notes: ME-180 cells were injected into the left flank and ME-180 CPR cells were injected into the right flank of nude mice. Once the ME-180 CPR tumors reached a size of 100 mm3, the mice were begun on treatment, regardless of the size of the ME-180 tumors on the left flank. Treatment was by daily gavage, consisting of 50% PEG in water for control and 250 mg/kg nelfinavir in 50% PEG for nelfinavir treatment. After 21 days of treatment, the mice were euthanized. (A) Whole body weights of each group of mice throughout treatment; ns indicates P>0.05. (B) Volume of ME-180 or (C) ME-180 CPR tumors, as measured by calipers.
Abbreviations: CPR, cisplatin-resistant; ns, nonsignificant; PEG, polyethylene glycol.