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. Author manuscript; available in PMC: 2016 Jun 8.
Published in final edited form as: Science. 2016 Apr 7;352(6282):175–180. doi: 10.1126/science.aaf4405

Fig. 2. HIF signaling regulates multiple steps within the metastatic cascade.

Fig. 2

Highlighted in brackets are direct target genes of HIF that promote each step of metastasis (to the lung, in the example shown). ECM, extracellular matrix; BMDC, bone marrow–derived cell.