Table 10.

Known genes that were differentially expressed in X-irradiated mouse brain regions relative to a matched, unirradiated control group using a non-FDR-adjusted statistical approach (p ≤ 0.05), with a minimum fold change of 1.5.

Brain region	Probe ID	Accession No.	Gene symbol	Fold change	Description
Auditory cortex	ILMN_2971479	NM_021897	Trp53inp1	1.91 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2634083	NM_007669	Cdkn1a	1.86 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
	ILMN_3081854	NM_001025245	Mbp	1.56 up	myelin basic protein, transcript variant 8
Amygdala	ILMN_2971479	NM_021897	Trp53inp1	1.97 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2634083	NM_007669	Cdkn1a	1.87 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
Caudate	ILMN_2750515	NM_010234	Fos	2.15 down	FBJ osteosarcoma oncogene
	ILMN_2634083	NM_007669	Cdkn1a	2.03 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
	ILMN_2800505	NM_010053	Dlx1	1.99 down	distal-less homeobox 1
	ILMN_2971479	NM_021897	Trp53inp1	1.84 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2701881	NM_010444	Nr4a1	1.81 down	nuclear receptor subfamily 4, group A, member 1
	ILMN_2860959	NM_010054	Dlx2	1.81 down	distal-less homeobox 2
	ILMN_2629112	NM_139306	Acer2	1.79 up	alkaline ceramidase 2, transcript variant 1
	ILMN_2855315	NM_015786	Hist1h1c	1.60 up	histone cluster 1, H1c
	ILMN_2656748	NM_010145	Ephx1	1.52 up	epoxide hydrolase 1, microsomal
	ILMN_2628567	NM_013750	Phlda3	1.52 up	pleckstrin homology-like domain, family A, member 3
Cerebellum	ILMN_2634083	NM_007669	Cdkn1a	3.00 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
	ILMN_2971479	NM_021897	Trp53inp1	2.31 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2923607	NM_013750	Phlda3	1.78 up	pleckstrin homology-like domain, family A, member 3
	ILMN_1256476	NM_022032	Perp	1.57 up	PERP, TP53 apoptosis effector
	ILMN_2629112	NM_139306	Acer2	1.51 up	alkaline ceramidase 2, transcript variant 1
Hippocampus	ILMN_2971479	NM_021897	Trp53inp1	2.34 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2634083	NM_007669	Cdkn1a	2.29 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
	ILMN_1229726	NM_178887	Fibcd1	1.92 down	fibrinogen C domain containing 1
	ILMN_2750515	NM_010234	Fos	1.71 down	FBJ osteosarcoma oncogene
	ILMN_2628567	NM_013750	Phlda3	1.61 up	pleckstrin homology-like domain, family A, member 3
	ILMN_2701881	NM_010444	Nr4a1	1.57 down	nuclear receptor subfamily 4, group A, member 1
Hypothalamus	ILMN_2634083	NM_007669	Cdkn1a	2.75 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
	ILMN_2971479	NM_021897	Trp53inp1	2.43 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2750515	NM_010234	Fos	1.75 down	FBJ osteosarcoma oncogene
	ILMN_2656748	NM_010145	Ephx1	1.69 up	epoxide hydrolase 1, microsomal
Medial prefrontal cortex	ILMN_2750515	NM_010234	Fos	2.29 down	FBJ osteosarcoma oncogene
	ILMN_2971479	NM_021897	Trp53inp1	2.13 up	transformation related protein 53 inducible nuclear protein 1, transcript variant 1
	ILMN_2634083	NM_007669	Cdkn1a	1.67 up	cyclin-dependent kinase inhibitor 1A (P21), transcript variant 1
	ILMN_1235372	NM_008220	Hbb-bt	1.67 down	hemoglobin, beta adult t chain
	ILMN_2840082	NM_027571	P2ry12	1.50 down	purinergic receptor P2Y, G-protein coupled 12

FDR: false discovery rate.