. 2015 Dec 14;26(4):473–480. doi: 10.3109/14397595.2015.1109182

Table 2. Disease activity status at RCT baseline and CZP baseline.

	J-RAPID			HIKARI
	LD group (n = 82)	No-LD group (n = 61)		LD group (n = 116)	No-LD group (n = 99)
Characteristics, mean (SD), unless otherwise stated	DB baseline	DB baseline	OLE entry	DB baseline	DB baseline	OLE entry
DAS28(ESR) score	6.2 (0.8)	6.5 (0.8)	5.9 (1.3) ^a	6.1 (0.9)	6.3 (1.0)	6.2 (1.4)
No. of tender joints (0–68)	19.0 (9.0)	19.4 (9.3)	17.6 (11.7)	16.2 (9.6)	18.0 (10.5)	17.4 (13.4)
No. of swollen joints (0–66)	16.6 (8.4)	16.8 (8.3)	15.2 (11.1)	13.8 (7.5)	15.8 (8.7)	15.0 (10.1)
Patient’s assessment of pain (100 mm VAS)	55.6 (20.6)	60.6 (22.3)	50.9 (25.6) ^a	56.6 (21.2)	56.9 (21.2)	56.3 (24.5)
Patient’s assessment of global disease activity (100 mm VAS)	53.0 (19.6)	57.4 (21.5)	50.9 (25.7) ^a	54.1 (20.7)	55.7 (21.7)	57.8 (23.5)
Physician’s assessment of global disease activity (100 mm VAS)	61.2 (16.2)	65.1 (15.5)	54.0 (24.3) ^b	58.8 (17.5)	63.8 (17.6)	56.7 (25.4) ^c
CRP (mg/dL), geometric mean (CV)	1.4 (123.0)	1.6 (141.9)	1.3 (158.0)	1.7 (139.8)	1.7 (147.2)	1.7 (179.4)
ESR (mm/h), geometric mean (CV)	46.3 (60.9)	48.8 (47.0)	40.2 (61.1)	49.0 (50.3)	52.8 (52.8)	50.5 (71.5)
HAQ-DI score	1.13 (0.65)	1.14 (0.62)	0.95 (0.62) ^a	1.05 (0.68)	1.21 (0.69)	1.32 (0.72)

CRP, C-reactive protein; DAS28, 28-joint Disease Activity Score; ESR, erythrocyte sedimentation rate; HAQ-DI, Health Assessment Questionnaire – Disability Index; LD, loading dose; SD, standard deviation; VAS, visual analogue scale.

n = 60.

n = 59.

n = 98.