Fig. 1.

3D structures of the NPC that were solved using EM. The timeline shows representative structures of the NPC drawn to scale. The model organism, the method used and the reported resolution are indicated when applicable. Images have been modified from the cited references (extracted: NPCs were extracted from membranes using heparin and/or detergent; Nuc: NPCs were embedded in the NE of intact nuclei; NE: NPCs were embedded into isolated NEs; whole cell: data were acquired on the intact cells).