Table 2.

important/significant proteins found in the significant OPLS model of pain intensity in the CWP group

Spot number	Protein	VIP	Absolute P(corr)	CoeffCS	Type
6748	Creatine kinase M-type	1.56	0.62	–	M
2520	Myosin light chain 6B	1.55	0.68	+	C
2736	ankyrin repeat domain-containing protein 2	1.54	0.68	+	S
3648	Troponin T, slow skeletal muscle	1.49	0.67	+	C
6441	Troponin i, slow skeletal muscle	1.35	0.56	–	C
1327	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform	1.27	0.54	–	C
3851	Serum albumin	1.27	0.52	–	T
4535	Glutathione S-transferase Mu 2	1.24	0.52	+	S & i
3647	Troponin T, slow skeletal muscle	1.21	0.58	+	C
7525	Phosphoglycerate mutase 2	1.15	0.44	–	M
5642	Troponin T, slow skeletal muscle	1.02	0.45	–	C
5540	Voltage-dependent anion-selective channel protein 1	1.01	0.40	+	T

Notes: For each protein is reported ViP (ViP >1.0 is significant and only proteins with ViP >1 are shown), absolute P(corr), and sign of the coefficient (CoeffCS; + or –; R²=0.99, Q²=0.91, CV-aNOVa: P<0.001). Proteins with positive coefficients are positively correlated with the pain intensity, and proteins with negative coefficients are negatively correlated. The proteins were divided based on UniProt database (http://web.expasy.org) definition on biological process in different groups (labeled type).

Abbreviations: C, contractile proteins; CV-aNOVa, cross-validated analysis of variance; CWP, chronic widespread pain; M, metabolic proteins; OPLS, orthogonal partial least squares; S, structural proteins; S & i, stress and inflammatory proteins; T, transport proteins; ViP, variable influence on projection.