Table 3.
important/significant proteins found in the significant OPLS regression of PPT of trapezius bilaterally (ie, 2 Y-variables) in all subjects taken together (CWP and CON)
| Spot number | Protein | VIP | Absolute P(corr) | CoeffCS | Type |
|---|---|---|---|---|---|
| 2736 | ankyrin repeat domain-containing protein 2 | 1.51 | 0.73 | + | S |
| 5538 | *Carbonic anhydrase 3 | 1.46 | 0.73 | – | S & i |
| 5542 | *Triosephosphate isomerase | 1.41 | 0.65 | – | M |
| 1834 | *Keratin, type ii cytoskeletal 1 | 1.27 | 0.43 | – | S |
| 2742 | *Creatine kinase B-type | 1.27 | 0.49 | + | M |
| 5227 | Myoglobin | 1.22 | 0.47 | – | T |
| 6632 | *Glyceraldehyde-3-phosphate dehydrogenase | 1.21 | 0.53 | – | M |
| 6530 | *Carbonic anhydrase 3 | 1.13 | 0.59 | – | S & i |
| 3540 | *Heat shock protein β-1 | 1.10 | 0.42 | + | S & i |
| 6841 | aTP synthase subunit α, mitochondrial | 1.08 | 0.42 | – | M |
| 7732 | *Fructose-bisphosphate aldolase a | 1.05 | 0.47 | – | M |
Notes: For each protein is reported ViP (ViP >1.0 is considered significant and only proteins with ViP >1 are shown), absolute P(corr), and sign of the coefficient (CoefCS; + or –; R2=0.56, Q2=0.49, CV-aNOVa: P<0.001). Proteins with positive coefficients are positively correlated to PPT, and proteins with negative coefficients are negatively correlated. The proteins were divided based on UniProt database (http://web.expasy.org) definition on biological process in different groups (labeled type). Proteins marked with * were significant regressors in the regression of group membership presented in our previous article.39
Abbreviations: aTP, adenosine triphosphate; CON, controls; CV-aNOVa, cross-validated analysis of variance; CWP, chronic widespread pain; M, metabolic proteins; OPLS, orthogonal partial least squares; PPT, pressure pain threshold; S, structural proteins; S & i, stress and inflammatory proteins; T, transport proteins; ViP, variable influence on projection.