Table 1.

Medication and Dosage

Date	Supplement
Baseline	400 mg folic acid and 860 μg vitamin B12 Included in a complete coenzymated sublingual B-complex supplement, PO, BID
August 05, 2014 (First Visit)	800 μg L-5-MTHF and 1000 μg methyl-B12, PO, QD Included in a complete B-complex supplement
November 07, 2014	400 μg L-5-MTHF and 500 μg methyl-B12, PO, QD Included in a lozenge and vitamin B complex, PO, QD
	0.5 to 1 mg Ativan tablet, PRN
January 12, 2015	500 μg L-5-MTHF, PO, QD 500 μg methyl-B12, PO, QD Included in liquid B-vitamin complex supplement
	Begin 400 mg SAMe, PO, BID
February 09, 2015	Maintain January 12, 2015, B-vitamin protocol
	Continue SAM-e 400 mg, PO, BID, Monday, Wednesday, Friday Continue SAM-e 200 mg, PO, BID, Tuesday, Thursday No SAMe on Saturday or Sunday

Abbreviations: PO, orally; BID, twice per day; QD, every day; PRN, as needed; SAMe, S-adenosyl methionine.