Table 1.
Expression of serine/glycine metabolism-related proteins according to the subtype of thyroid cancer
| Parameters | Total n = 557 (%) | PTC n = 344 (%) | FC n = 112 (%) | MC n = 70 (%) | PDC n = 23 (%) | AC n = 8 (%) | P value |
|---|---|---|---|---|---|---|---|
| PHGDH in tumor | <0.001 | ||||||
| Negative | 252 (45.2) | 126 (36.6) | 58 (51.8) | 59 (84.3) | 5 (21.7) | 4 (50.0) | |
| Positive | 305 (54.8) | 218 (63.4) | 54 (48.2) | 11 (15.7) | 18 (78.3) | 4 (50.0) | |
| PSAT1 in tumor | 0.001 | ||||||
| Negative | 477 (85.6) | 280 (81.4) | 103 (92.0) | 69 (98.6) | 18 (78.3) | 7 (87.5) | |
| Positive | 80 (14.4) | 64 (18.6) | 9 (8.0) | 1 (1.4) | 5 (21.7) | 1 (12.5) | |
| PSPH in tumor | 0.008 | ||||||
| Negative | 497 (89.2) | 300 (87.2) | 101 (90.2) | 70 (100.0) | 18 (78.3) | 8 (100.0) | |
| Positive | 60 (10.8) | 44 (12.8) | 11 (9.8) | 0 (0.0) | 5 (21.7) | 0 (0.0) | |
| SHMT1 in tumor | <0.001 | ||||||
| Negative | 415 (74.5) | 236 (68.6) | 94 (83.9) | 63 (90.0) | 16 (69.6) | 6 (75.0) | |
| Positive | 142 (25.5) | 108 (31.4) | 18 (16.1) | 7 (10.0) | 7 (30.4) | 2 (25.0) | |
| SHMT1 in stroma | <0.001 | ||||||
| Negative | 413 (74.1) | 212 (61.6) | 112 (100.0) | 65 (92.9) | 21 (91.3) | 3 (37.5) | |
| Positive | 144 (25.9) | 132 (38.4) | 0 (0.0) | 5 (7.1) | 2 (8.7) | 5 (62.5) | |
| GLDC in tumor | 0.529 | ||||||
| Negative | 470 (84.4) | 285 (82.8) | 96 (85.7) | 60 (85.7) | 21 (91.3) | 8 (100.0) | |
| Positive | 87 (15.6) | 59 (17.2) | 16 (14.3) | 10 (14.3) | 2 (8.7) | 0 (0.0) | |
PTC papillary thyroid carcinoma; FC follicular carcinoma; MC medullary carcinoma; PDC poorly differentiated carcinoma; AC anaplastic carcinoma; PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
Italic values represent p < 0.05