Table 3.
Expression of serine/glycine metabolism-related proteins in follicular neoplasm
| Parameters | Total n = 264 (%) | Follicular adenoma n = 152 (%) | Follicular carcinoma n = 112 (%) | p value |
|---|---|---|---|---|
| PHGDH in tumor | 0.274 | |||
| Negative | 147 (55.7) | 89 (58.6) | 58 (51.8) | |
| Positive | 117 (44.3) | 63 (41.4) | 54 (48.2) | |
| PSAT1 in tumor | 0.001 | |||
| Negative | 219 (82.6) | 116 (75.8) | 103 (92.0) | |
| Positive | 46 (17.4) | 37 (24.2) | 9 (8.0) | |
| PSPH in tumor | 0.328 | |||
| Negative | 244 (92.1) | 143 (93.5) | 101 (90.2) | |
| Positive | 21 (7.9) | 10 (6.5) | 11 (9.8) | |
| SHMT1 in tumor | 0.137 | |||
| Negative | 211 (79.6) | 117 (76.5) | 94 (83.9) | |
| Positive | 54 (20.4) | 36 (23.5) | 18 (16.1) | |
| GLDC in tumor | 0.262 | |||
| Negative | 234 (88.3) | 138 (90.2) | 96 (85.7) | |
| Positive | 31 (11.7) | 15 (9.8) | 16 (14.3) | |
PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
Italic value represents p < 0.05