Table 2.
Study | Sample size estimation | Event/total | Censoring | Survival curve | Shape of KM-curve | Significance | Regression model | Variable selection | Goodness of fit or PH assumption test |
---|---|---|---|---|---|---|---|---|---|
Attal [9] | Yes | 86/135 (relapse) | NR | KM method, log-rank test | Crossing, overlapping | S | Cox-PH model | Informal | NR |
Bernasconi [10] | NR | NR | NR | KM method, log-rank test | Crossing | NS | N/A | N/A | NR |
Cornelissen [11] | NR | 102/257 (death), 113/257 (relapse) | Yes | KM method, log-rank test | Crossing | NS | Cox-PH model, interaction, competing risk | Informal | NR |
De Witte [12] | NR | 32/66 (death) | NR | KM method, log-rank test, Wilcoxon test | Crossing, overlapping | S | N/A | N/A | NR |
Fielding [13] | NR | 116/165 (death) | NR | KM method, log-rank test | Crossing | NS | N/A | N/A | NR |
Goldstone [14] | NR | 531/1031 (death) | Yes | KM method, log-rank test | Crossing, overlapping | NS | Cox-PH model | N/A | NR |
Hunault [15] | Yes | 67/147 (death) | NR | KM method, log-rank test | Crossing | S | Cox-PH model | Informal | NR |
Ifrah [16] | Yes | 37/50 (relapse) | NR | KM method, log-rank test | Curves were plotted in two different graphs | N/A | Cox-PH model | Informal | NR |
Labar [17] | NR | 245/340 (death), 131/340 (relapse) | Yes | KM method, log-rank test | Crossing, overlapping | NS | Cox-PH model | Informal | NR |
Ribera [18] | Yes | 144/182 (death), 88/182 (relapse) | Yes | KM method, log-rank test | Crossing | NS | Cox-PH model | Informal | NR |
Sebban [19] | NR | 146/255 (death) | NR | KM method, log-rank test | Crossing | NS | N/A | N/A | NR |
Thomas [21] | NR | 177/259 (relapse) | NR | KM method, log-rank test | Unevenly separate | S | Cox-PH model | Informal | NR |
Takeuchi [20] | NR | 83/142 (death) | Yes | KM method, log-rank test | Crossing, overlapping | NS | Cox-PH model | Informal | NR |
Ueda [22] | NR | 38/57 (death) | Yes | KM method, log-rank test, Wilcoxon test | Evenly separate | S | Cox-PH model | Informal | NR |
Abbreviation: PH proportional hazard, NR not reported, N/A not applicable; S, statistical significance; NS, non-statistical significance