Table 1.
Body weight, blood pressure and metabolic parameters 8 weeks after RDN
| SD-sham n = 5 | SD-RDN n = 6 | ApoE−/−-sham n = 5 | ApoE−/−-RDN n = 6 | |
|---|---|---|---|---|
| Body weight (g) | 456.2 ± 25.64 | 474.14 ± 11.26 | 446.75 ± 3.68 | 456.2 ± 10 |
| Heart weigth (g) | 1.41 ± 0.04 | 1.45 ± 0.05 | 1.51 ± 0.06 | 1.45 ± 0.04 |
| Heart rate (bpm) | 360 ± 9 | 370 ± 10 | 341 ± 13 | 359 ± 7 |
| Blood pressure (mmHg) | ||||
| Systolic | 144 ± 5 | 137 ± 4 | 148 ± 12 | 136 ± 7 |
| Diastolic | 116 ± 4 | 109 ± 10 | 121 ± 11 | 99 ± 8 |
| Stroke volume (µl) | 210 ± 10 | 219 ± 5 | 203 ± 10 | 224 ± 9 |
| Ejection fraction (%) | 61 ± 3 | 61 ± 1 | 59 ± 2 | 60 ± 2 |
| LVEDV (µl) | 342 ± 11 | 357 ± 11 | 344 ± 8 | 372 ± 13 |
| LVESV (µl) | 131 ± 12 | 137 ± 8 | 140 ± 11 | 148 ± 10 |
| Serum chemistry | ||||
| GPT (U/l) | 79.64 ± 7.53 | 70.5 ± 5.91* | 109.66 ± 14.96 | 104.43 ± 10.26 |
| GOT (U/l) | 178.36 ± 24.74 | 169.64 ± 13.83 | 222.22 ± 33.31 | 217.28 ± 32.1 |
| Creatinine (mg/dl) | 0.306 ± 0.02 | 0.33 ± 0.01 | 0.33 ± 0.02 | 0.29 ± 0.03 |
| Glucose (mg/dl) | 235.2 ± 8.24 | 268.71 ± 17.18 | 328.25 ± 28.51 | 289.33 ± 25.65 |
| Cholesterol (mg/dl) | 48.2 ± 3.28§ | 45.71 ± 3.21# | 131.5 ± 17.54 | 152.5 ± 13.63 |
| Triglycerides (mg/dl) | 30.6 ± 7.04§ | 30.57 ± 8.05# | 152.2 ± 27.41 | 152.5 ± 18.44 |
| LDL (mg/dl) | 10.96 ± 1.15§ | 10.5 ± 0.94# | 52.3 ± 6.62 | 65.28 ± 9.61 |
| HDL (mg/dl) | 37.58 ± 1.36§ | 34.93 ± 3.36# | 11.7 ± 1.67 | 15.78 ± 1.81 |
Values are mean ± SEM
LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, GPT glutamat-pyruvat-transaminase, GOT glutamat-oxalacetat-transaminase, HDL high-density lipoprotein, LDL low-density lipoprotein
* p < 0.05 SD-RDN vs. ApoE−\−-RDN
§p < 0.01 SD-sham vs. ApoE−\−-sham
#p < 0.01 SD-RDN vs. ApoE−\−-RDN (one-way-Anova followed by Tukey´s multiple comparisons test)