Table 2.
Maximal relaxation (E max) and half-maximal dose (logEC50) in response to carbachol and glyceryl trinitrate in 16 weeks old rats
| SD-sham | SD-RDN | ApoE−/−-sham | ApoE−/−-RDN | |
|---|---|---|---|---|
| Number of rats | 5 | 5 | 5 | 5 |
| Response to carbachol | ||||
| E max, (%) | 67 ± 6.0 | 73 ± 3.3 | 43 ± 4.8§ | 53 ± 4.9 |
| logEC50 (log M) | −6.22 ± 0.06 | −6.17 ± 0.03 | −5.81 ± 0.15 | −5.88 ± 0.12 |
| Response to glyceryl trinitrate | ||||
| E max, (%) | 232 ± 24 | 237 ± 6 | 209 ± 13 | 217 ± 16 |
| logEC50 (log M) | −6.5 ± 0.10 | −6.47 ± 0.08 | −6.32 ± 0.06 | −6.29 ± 0.10 |
Values are mean ± SEM. p values were calculated using one-way-Anova followed by Tukey´s multiple comparisons test
§p = 0.01 SD-sham vs. ApoE−\−-sham