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. 2016 Jun 8;14:165. doi: 10.1186/s12967-016-0921-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effects of GSZD on the severity of arthritis in AIA rats. a Macroscopic evidence of arthritis such as redness or swelling was obviously observed in AIA rats of the model group, while doses of 18.6 g/(kg day) GSZD and 0.2 mg/(kg day) MTX significantly reduced the severity of arthritis in AIA rats; b Doses of 4.65–18.6 g/(kg day) GSZD and 0.2 mg/(kg day) MTX significantly reduced the mean arthritis score of AIA rats; c Doses of 4.65–18.6 g/(kg day) GSZD and 0.2 mg/(kg day) MTX significantly reduced the arthritis incidence of AIA rats; d Doses of 4.65–18.6 g/(kg day) GSZD and 0.2 mg/(kg day) MTX significantly reduced the percentage of arthritis limbs of AIA rats; e Doses of 9.3 g/(kg day) and 18.6 g/(kg day) GSZD, and 0.2 mg/(kg day) MTX effectively extended the time of arthritis first appeared of AIA rats. Data are represented as the mean ± SD. ^#P < 0.05, comparison with the normal control (Con). *, **, and ***, P < 0.05, P < 0.01, and P < 0.001, respectively, comparison with the model control (Mod)