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. 2016 Jun 8;14:165. doi: 10.1186/s12967-016-0921-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effect of GSZD on histologic lesions of AIA rats. a Inflammatory changes observed in different groups using H & E staining (×200); b Articular cartilage changes observed in different groups using H & E staining (×200); c Cartilage changes observed in different groups using toluidine blue staining; (×200); d Bone destruction changes observed in different groups using H & E staining (×200); e–g showed the inflammation score, the bone destruction score and the loss of toluidine blue staining in joints respectively, calculated as described in “Methods” section. Data are represented as the mean ± SD. *, **, and ***, P < 0.05, P < 0.01, and P < 0.001, respectively, in contrast with the model control (Mod)