Fig. 1.

Dysregulated expression of miRNAs in HT. a Microarray data with significant gene expression changes of ≥twofold (P < 0.05). In total, 39 miRNAs showed different expression profiles between HT and normal thyroid using miRNA microarray. Of these, 22 miRNAs were upregulated and 17 miRNAs were downregulated. b Comparison of miRNA fold changes using miRNA microarray and qRT-PCR analysis. The fold change value of each miRNA was calculated by comparing the expression levels of HT samples with normal thyroid (n = 10 for each group). A total of six miRNAs were selected and three of them were confirmed by qRT-PCR. *P < 0.001. c HT-associated upregulation of miR-142-5p, miR-142-3p, and miR-146a expression patterns in various types of thyroid disease. Normal thyroid tissues (n = 21); HT primary Hashimoto’s thyroiditis (n = 42); HT/NG Hashimoto’s thyroiditis with nodular goiter (n = 15); HT/PTC Hashimoto’s thyroiditis with papillary thyroid carcinoma (n = 14); NG nodular goiter (n = 30); PTC papillary thyroid carcinoma (n = 20). *P < 0.001