Table 1.
Activity of Plasmodium PSD inhibitors against Plasmodium falciparum 3D7 and human foreskin fibroblast (HFF).
| Compound ID | MW | ALogP |
P. falciparum 3D7 (EC50 in μM) |
HFF (IC50 in μM) |
SI: HFF/3D7 |
|---|---|---|---|---|---|
| MMV665927 | 282.55 | 2.87 | 0.555 | 16.2 | 29 |
| MMV666106 | 436.57 | 5.13 | 1.07 | >32 | >30 |
| MMV019555 | 478.67 | 8.06 | 0.376 | 4.06 | 11 |
| MMV666026 | 288.30 | 3.66 | 3.845 | >32 | >8 |
| MMV019918 | 383.71 | 3.93 | 0.8 | 4.028 | 5 |
| MMV665949 | 281.13 | 4.12 | 2.47 | >32 | >13 |
| MMV666025 | 500.19 | 5.97 | 1.26 | >32 | >25 |
| MMV396594 | 490.66 | 5.52 | 1.06 | >32 | >30 |
| MMV665971 | 484.95 | 4.86 | 1.14 | 16.594 | >15 |
| MMV019064 | 493.60 | 4.62 | 1.3 | >32 | 25 |
| MMV001239 | 400.45 | 3.74 | 15 | >32 | >2 |
| MMV007764 | 256.39 | 4.93 | 0.716 | 19.329 | >27 |
| MMV019266 | 312.41 | 4.46 | 0.615 | >32 | >52 |
| MMV000356 | 379.26 | 4.16 | 1.03 | >32 | >31 |
| MMV007285 | 298.77 | 4.56 | 4 | >32 | >8 |
| MMV011099 | 275.31 | 3.52 | 0.242 | >32 | >132 |
| MMV665797 | 364.44 | 5.02 | 0.584 | 14.254 | 24 |
| MMV020243 | 362.43 | 2.54 | 1.15 | 23.776 | 21 |
The selectivity index (SI) for each compound was determined as a ratio of HFF IC50/3D7 EC50. Data were obtained from MMV and Chembl2028072.