Figure 2.
Migratory activity and network forming activity of endothelial progenitor cells (EPCs) differing between subjects with chronic coronary artery disease (CAD) and subjects with acute myocardial infarction (AMI). (A) Migratory activity of CD34+CD133+ cell-derived EPCs assessed by modified Boyden chamber methods. Both in subjects <65 years old and in subjects ≥65 years old, migratory activity was significantly enhanced in EPCs from AMI compared with EPCs from stable CAD (p<0.05). Interestingly, enhanced migratory activity of EPCs was observed even in AMI subjects ≥65 years old. (B) Similar to migratory activity, the ability of network-forming activity of CD34+CD133+ cell-derived EPCs with human umbilical vein endothelial cells was improved in AMI compared with stable CAD. The statistically significant difference was only observed in subjects ≥65 years old.
