Fig 1.

(A) Novel object recognition tasks. Mice were exposed to three objects during two 10-min sample phases. After either an immediate (approximately 30 sec), 10-min, or 24-h delay, mice were returned to the arena for the test phase, during which one of the objects was replaced with a novel object. (Bi) Object-in-place task. Mice were exposed to three objects during two 10-min sample phases. After a delay of either 24-h, or immediately following the sample stage, mice were returned to the arena for the test phase. During the test, two of the objects swapped their spatial location (see arrow). (Bii) Object location task. Mice were exposed to three identical objects during two 10-min sample phases. After a delay of 10-min, mice were returned to the arena for the test phase, during which one of the objects was moved from its original location to a previously vacant corner of the arena. (C) Novel Odour Recognition. Mice were exposed to three visually identical cubes each containing a different odour during two 10-min sample phases. After a delay of either 10-min or 24-h, mice were returned to the arena for the test phase. During the test, one of the odour cubes was replaced with a cube containing a novel odour.