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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: Biochem J. 2016 Mar 8;473(10):1329–1341. doi: 10.1042/BJ20151410

Figure 6. APPIM17G/I18F/F34V displays improved complementarity with the mesotrypsin S3′ subsite.

Figure 6

(A) APPIWT shows limited interactions with the mesotrypsin S3′ subsite. Mesotrypsin cartoon and surface are shown in gray, with Phe-41 and Lys-60 in orange; APPIWT is shown in blue, with Ile-18 in cyan (PDB entry: 3L33). (B) Phe-18 of APPIM17G/I18F/F34V forms hydrophobic, ring-stacking, and amino-aromatic interactions with mesotrypsin Phe-41 and Lys-60 residues. Mesotrypsin is rendered and colored as above, with APPIM17G/I18F/F34V in yellow and mutated residues in green.