Table 2.

The inhibitor specificity of APPI-M17G/118F/F34V towards a range of human serine proteases

Inhibitor	Ki for mesotrypsin (M)‡	Ki for kallikrein-6(M)‡	Ki for cationic trypsin(M)‡	Ki for anionic trypsin (M)‡	Ki for FXla (M)‡
APPI-WT	(1.31±0.17)×10−7	(2.23±0.18)×10−9	(6.27±1.01)×10−12	(1.74±0.05)×10−12	(4.1±0.14)×10−10
APPI-M17G/118F/F34V	(89.8±0.23)×10−12	(1.09±0.12) ×10−9	(4.96±0.25) ×10−12	(1.47±0.02×10−12	(9.84±0.32)×10−8
Ki (fold)	1459	2.04	1.3	1.18	4.16×10−3
$\text{Specificity}\left(\frac{K_i(\mathit{fold})\text{for}\text{Mesotrypsin}}{K_i(\mathit{fold})\text{for}\text{protease}X}\right)$	1	715	1122	1236	350000

^‡Values are means ± SD.