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A. Structural domains of human Y-family TLS DNA polymerases Rev1, Polη, Polι, Polκ3-7. The core polymerase domain consists of the palm, finger and thumb domains, and a polymerase associated domain (PAD) unique to Y-family TLS enzymes. In addition, Y-family TLS polymerases possess accessory domains and motifs that mediate a range of protein-protein interactions. B. Subunits of human B-family TLS DNA polymerase Polζ and their domain arrangement42 (see text for details).
